Medical Laboratory Scientist ASCP Practice Exam 2025 – Complete Study Guide

Coulometry is a quantitative technique used to analyze the amount of a substance in a solution by measuring the electric charge required to completely react the species of interest. The method is particularly effective for halides, such as chloride ions, as it often involves a titration process where a controlled electric current facilitates the reaction. In this context, silver ions are commonly used as titrants because they react with halides to form insoluble silver salts.

This technique is widely regarded for its high accuracy and precision in measuring concentrations, especially in cases where traditional volumetric titration may face limitations, such as in microanalysis. The ability to generate silver ions during the reaction further exemplifies how coulometry operates, making the description of an automated method for measuring chloride through silver ion generation accurate and representative of the technique.

The other choices refer to distinct laboratory methods that do not align with the principles of coulometry. For instance, measuring blood gas levels involves different analytical approaches typically using electrodes rather than charge measurement. The determination of enzyme activity often relies on spectrophotometric methods rather than electrical charge, and high-performance liquid chromatography is a separate analytical technique used for separating and analyzing compounds in a mixture. Thus, the description of coulometry as an automated method for