Medical Laboratory Scientist ASCP Practice Exam 2025 – Complete Study Guide

Question: 1 / 400

What is the most frequent genotype among Rho (D) negative individuals?

RR

Rr

Rr'Rr

rr

The most frequent genotype among Rho (D) negative individuals is rr. This is primarily due to the inheritance patterns of the Rh blood group system, where the presence or absence of the D antigen is determined by specific alleles. The "R" alleles (R and r) are dominant, meaning that the presence of at least one R allele results in a positive Rh phenotype. Individuals with the genotype rr lack the D antigen entirely, which classifies them as Rho (D) negative.

In populations, the frequency of the rr genotype is higher compared to any combinations involving the dominant alleles (like Rr or RR). Therefore, the correct answer reflects the genetic makeup of the majority of Rho (D) negative individuals. Understanding this context is essential for interpreting blood group genetics and their implications in transfusion medicine and pregnancy considerations.

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