Medical Laboratory Scientist ASCP Practice Exam 2025 – Complete Study Guide

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What are the lab values typically associated with Wilson's Disease?

Low serum copper and increased plasma ceruloplasmin

Low values of plasma ceruloplasmin, increased urine copper, and increased serum copper

Wilson's Disease is a genetic disorder that leads to excessive accumulation of copper in the body, particularly affecting the liver and brain. The laboratory values typically associated with Wilson's Disease include low plasma ceruloplasmin and high urine copper levels, as well as increased serum copper.

In Wilson's Disease, the liver's ability to excrete copper into bile is impaired, resulting in copper buildup in the liver and subsequently leading to its release into the bloodstream. Ceruloplasmin is a copper-carrying protein; in Wilson's Disease, due to reduced synthesis or functioning of ceruloplasmin, the plasma levels often decrease. This results in elevated copper levels in the urine as the body tries to eliminate the excess copper.

By contrasting these values with the other options, it becomes clear that the values in option B accurately reflect the pathophysiology of Wilson's Disease, while the others misrepresent the expected findings in patients with this condition.

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Normal serum copper with decreased urine copper

Increased plasma ceruloplasmin and normal urine copper

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