Medical Laboratory Scientist ASCP Practice Exam 2025 – Complete Study Guide

The activation processes related to coagulation factors are crucial for understanding hemostasis and the subsequent effects of deficiencies. Factor XII, also known as Hageman factor, plays a role in initiating the intrinsic pathway of coagulation, and its deficiency primarily impacts other factors in that pathway.

Fibrin lysis activation refers to the breakdown of fibrin in a clot and is generally associated with the action of plasminogen being converted to plasmin. This process is primarily regulated by a balance of coagulation and fibrinolysis factors, rather than directly involving Factor XII. The activation of fibrinolysis does not typically depend on the presence or absence of Factor XII, which is why a deficiency of this factor would not lead to its activation.

Kinin formation and Factor XI activation by thrombin are processes that can be influenced by the actions of Factor XII. Kinin formation is connected to the contact activation pathway, where Factor XII helps initiate the kinin cascade. Additionally, while thrombin can activate Factor XI, this activation pathway is affected by deficiencies in Factor XII, which leads to complications in the coagulation cascade.

Platelet aggregation can also be influenced by deficiencies in the coagulation cascade since Factor XII can activate other factors that promote clot formation and platelet activation